Adenosine A2A receptor as a potential regulator of Mycobacterium leprae survival mechanisms: new insights into leprosy neural damage

• Main Authors: Plinio Marcos Freire dos Santos (Author), Chyntia Carolina Díaz Acosta (Author), Thabatta Leal Silveira Andrezo Rosa (Author), Michelle Harumi Ishiba (Author), André Alves Dias (Author), Antonio Marcos Rodrigues Pereira (Author), Luísa Domingos Gutierres (Author), Melissa Pontes Pereira (Author), Matheus da Silva Rocha (Author), Patrícia Sammarco Rosa (Author), Daniele F. F. Bertoluci (Author), José Roberto Meyer-Fernandes (Author), Fabricio da Mota Ramalho Costa (Author), Maria Angela M. Marques (Author), John T. Belisle (Author), Roberta Olmo Pinheiro (Author), Luciana Silva Rodrigues (Author), Maria Cristina Vidal Pessolani (Author), Marcia Berrêdo-Pinho (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae, which can lead to a disabling neurodegenerative condition. M. leprae preferentially infects skin macrophages and Schwann cells-glial cells of the peripheral nervous system. The infection modifies the host cell lipid me...