RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.

• Main Authors: Maha-Hamadien Abdulla (Author), Theresa O'Brien (Author), Zachary B Mackey (Author), Mohamed Sajid (Author), Dennis J Grab (Author), James H McKerrow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an in vivo mouse model and an in vitro model of the blood-brain barrier. Doxycycline induction of RNAi targeting cathepsin B led to parasite clea...