Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors
Background: ORIN1001, a first-in-class oral IRE1-α endoribonuclease inhibitor to block the activation of XBP1, is currently in clinical development for inhibiting tumor growth and enhancing the effect of chemical or targeted therapy. Early establishment of a population pharmacokinetic (PopPK) model...
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Frontiers Media S.A.,
2024-03-01T00:00:00Z.
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