Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

• Main Authors: Xiaoqing Li (Author), Yunhai Bo (Author), Qingping Zeng (Author), Lei Diao (Author), Stephanie Greene (Author), John Patterson (Author), Lu Liu (Author), Fen Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: ORIN1001, a first-in-class oral IRE1-α endoribonuclease inhibitor to block the activation of XBP1, is currently in clinical development for inhibiting tumor growth and enhancing the effect of chemical or targeted therapy. Early establishment of a population pharmacokinetic (PopPK) model...