Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection

• Main Authors: Xingang Yao (Author), Songxin Guo (Author), Wenyu Wu (Author), Jinan Wang (Author), Shengen Wu (Author), Shijun He (Author), Yihong Wan (Author), Kutty Selva Nandakumar (Author), Xiaoguang Chen (Author), Ning Sun (Author), Qiuhua Zhu (Author), Shuwen Liu (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) annually infects 400 million people worldwide. Unfortunately, there is lack of widely protective vaccine or drugs against DENV. The viral RNA-dependent RNA polymerase (RdRp) of NS5 protein is highly conserved among different DENV subtypes, thus presenting itself as an attractive...