Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice

• Main Authors: Manuela Rinaldi (Author), Karen Maes (Author), Stéphanie De Vleeschauwer (Author), Debby Thomas (Author), Erik K. Verbeken (Author), Marc Decramer (Author), Wim Janssens (Author), Ghislaine N. Gayan-Ramirez (Author)
• Format: Book
• Published: The Company of Biologists, 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Mouse models of chronic obstructive pulmonary disease (COPD) focus on airway inflammation and lung histology, but their use has been hampered by the lack of pulmonary function data in their assessment. Systemic effects such as muscle dysfunction are also poorly modeled in emphysematous mice....