Pharmacological Evaluation of 3-Carbomethoxy Fentanyl in Mice

• Main Authors: Zeljko Mikovic (Author), Marko Kadija (Author), Cedomir Vucetic (Author), Katarina Savic Vujovic (Author), Ljiljana Dosen-Micovic (Author), Milovan Ivanovic (Author), Sonja Vuckovic (Author), Milica Prostran (Author)
• Format: Book
• Published: MDPI AG, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In many animal species, as well as in humans, high doses of fentanyl (F) produce marked neurotoxic effects, such as muscular rigidity and respiratory depression. The antinociception (hot-plate test), impairment of motor coordination (rotarod test) and acute toxicity of intraperitoneal newly synthesi...