Predicting treatment response to vancomycin using bacterial DNA load as a pharmacodynamic marker in premature and very low birth weight neonates: A population PKPD study

• Main Authors: Amadou Samb (Author), Rimke De Kroon (Author), Koos Dijkstra (Author), Marre Van Den Brand (Author), Martine Bos (Author), Frank Van Den Dungen (Author), Agnes Veldkamp (Author), Bram Wilhelm (Author), Timo R. De Haan (Author), Yuma A. Bijleveld (Author), Marceline Tutu Van Furth (Author), Paul Savelkoul (Author), Noortje Swart (Author), Ron Mathot (Author), Mirjam Van Weissenbruch (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: While positive blood cultures are the gold standard for late-onset sepsis (LOS) diagnosis in premature and very low birth weight (VLBW) newborns, these results can take days, and early markers of possible treatment efficacy are lacking. The objective of the present study was to investiga...