Schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating Akt expression and upregulating p53 and DR5 expression.

• Main Authors: Jianxin Wang (Author), Feifan Xu (Author), Dandan Zhu (Author), Yinong Duan (Author), Jinling Chen (Author), Xiaolei Sun (Author), Xue He (Author), Pan Li (Author), Wei Sun (Author), Jinrong Feng (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression of liver fibrosis. Previous studies have demonstrated the ability of soluble egg antigens (SEA) from schistosomes to inhibit HSC activation and to induce apoptosis in vitro. In this...