Strategies for Improving siRNA-Induced Gene Silencing Efficiency

• Main Authors: Fatemeh Safari (Author), Solmaz Rahmani Barouji (Author), Ali Mohammad Tamaddon (Author)
• פורמט: ספר
• יצא לאור: Tabriz University of Medical Sciences, 2017-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Purpose: Human telomerase reverse transcriptase (hTERT) plays a crucial role in tumorigenesis and progression of cancers. Gene silencing of hTERT by short interfering RNA (siRNA) is considered as a promising strategy for cancer gene therapy. Various algorithms have been devised for designing a high...