Elevated ABCB1 Expression Confers Acquired Resistance to Aurora Kinase Inhibitor GSK-1070916 in Cancer Cells

• Main Authors: Zhuo-Xun Wu (Author), Yuqi Yang (Author), Jing-Quan Wang (Author), Wen-Min Zhou (Author), Junyu Chen (Author), Yi-Ge Fu (Author), Ketankumar Patel (Author), Zhe-Sheng Chen (Author), Jian-Ye Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of multidrug resistance (MDR) has been a major issue for effective cancer chemotherapy as well as targeted therapy. One prominent factor that causes MDR is the overexpression of ABCB1 transporter. In the present study, we revealed that the Aurora kinase inhibitor GSK-1070916 is a subst...