MDMA Impairs Response to Water Intake in Healthy Volunteers

• Main Authors: Matthew J. Baggott (Author), Kathleen J. Garrison (Author), Jeremy R. Coyle (Author), Gantt P. Galloway (Author), Allan J. Barnes (Author), Marilyn A. Huestis (Author), John E. Mendelson (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic...