Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

• Main Authors: Shengyong Ng (Author), Sandra March (Author), Ani Galstian (Author), Kirsten Hanson (Author), Tânia Carvalho (Author), Maria M. Mota (Author), Sangeeta N. Bhatia (Author)
• Format: Book
• Published: The Company of Biologists, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Homeostasis of mammalian cell function strictly depends on balancing oxygen exposure to maintain energy metabolism without producing excessive reactive oxygen species. In vivo, cells in different tissues are exposed to a wide range of oxygen concentrations, and yet in vitro models almost exclusively...