Combined antitumoral effects of pretubulysin and methotrexate

• Main Authors: Sarah Kern (Author), Ines Truebenbach (Author), Miriam Höhn (Author), Jan Gorges (Author), Uli Kazmaier (Author), Stefan Zahler (Author), Angelika M. Vollmar (Author), Ernst Wagner (Author)
• Format: Book
• Published: Wiley, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Pretubulysin (PT), a potent tubulin‐binding antitumoral drug, and the well‐established antimetabolite methotrexate (MTX) were tested separately or in combination (PT+MTX) for antitumoral activity in L1210 leukemia cells or KB cervix carcinoma cells in vitro and in vivo in NMRI‐nu/nu tumor m...