Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1

• Main Authors: You-Jin Choi (Author), Sung Ho Yun (Author), Jihyeon Yu (Author), Yewon Mun (Author), Wonseok Lee (Author), Cheon Jun Park (Author), Byung Woo Han (Author), Byung-Hoon Lee (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Alterations in lipid metabolism are associated with aging and age-related diseases. Chaperone-mediated autophagy (CMA) is a lysosome-dependent process involved in specific protein degradation. Heat shock cognate 71 kDa protein (Hsc70) recognizes cytosolic proteins with KFERQ motif and all...