Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1

• Hoofdauteurs: You-Jin Choi (Auteur), Sung Ho Yun (Auteur), Jihyeon Yu (Auteur), Yewon Mun (Auteur), Wonseok Lee (Auteur), Cheon Jun Park (Auteur), Byung Woo Han (Auteur), Byung-Hoon Lee (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: Alterations in lipid metabolism are associated with aging and age-related diseases. Chaperone-mediated autophagy (CMA) is a lysosome-dependent process involved in specific protein degradation. Heat shock cognate 71 kDa protein (Hsc70) recognizes cytosolic proteins with KFERQ motif and all...