Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1

• Principais autores: You-Jin Choi (Autor), Sung Ho Yun (Autor), Jihyeon Yu (Autor), Yewon Mun (Autor), Wonseok Lee (Autor), Cheon Jun Park (Autor), Byung Woo Han (Autor), Byung-Hoon Lee (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2023-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: Alterations in lipid metabolism are associated with aging and age-related diseases. Chaperone-mediated autophagy (CMA) is a lysosome-dependent process involved in specific protein degradation. Heat shock cognate 71 kDa protein (Hsc70) recognizes cytosolic proteins with KFERQ motif and all...