Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

Previously, we synthesized curcumin and a succinate ester prodrug of curcumin namely curcumin diethyl disuccinate (CurDD) in the lab scale, which yielded hundred milligrams to few grams of the compounds. CurDD was found to be more stable in a phosphate buffer pH 7.4 and exhibited better cytotoxicity...

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Main Authors: Chawanphat Muangnoi (Author), Pahweenvaj Ratnatilaka Na Bhuket (Author), Ponsiree Jithavech (Author), Wisut Wichitnithad (Author), Onsiri Srikun (Author), Chakkrapan Nerungsi (Author), Suthiluk Patumraj (Author), Pornchai Rojsitthisak (Author)
Format: Book
Published: MDPI AG, 2019-08-01T00:00:00Z.
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