High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells

• Egile Nagusiak: Alejandro N. Rondón-Ortiz (Egilea), Christian L. Lino Cardenas (Egilea), Jimena Martínez-Málaga (Egilea), Ana L. Gonzales-Urday (Egilea), Kuljeet S. Gugnani (Egilea), Mark Böhlke (Egilea), Timothy J. Maher (Egilea), Alejandro J. Pino-Figueroa (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic receptor involved in the uptake of a variety of molecules, such as apoE, α2-macroglobulin, and the amyloid β peptide (Aβ), for either transcellular transport, protein trafficking or lysosomal degradation. The LRP1 gene can be...