High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells

• Main Authors: Alejandro N. Rondón-Ortiz (Author), Christian L. Lino Cardenas (Author), Jimena Martínez-Málaga (Author), Ana L. Gonzales-Urday (Author), Kuljeet S. Gugnani (Author), Mark Böhlke (Author), Timothy J. Maher (Author), Alejandro J. Pino-Figueroa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic receptor involved in the uptake of a variety of molecules, such as apoE, α2-macroglobulin, and the amyloid β peptide (Aβ), for either transcellular transport, protein trafficking or lysosomal degradation. The LRP1 gene can be...