C-terminal domain deletion enhances the protective activity of cpa/cpb loaded solid lipid nanoparticles against Leishmania major in BALB/c mice.

• Main Authors: Delaram Doroud (Author), Farnaz Zahedifard (Author), Alireza Vatanara (Author), Yasaman Taslimi (Author), Rouholah Vahabpour (Author), Fatemeh Torkashvand (Author), Behrooz Vaziri (Author), Abdolhossein Rouholamini Najafabadi (Author), Sima Rafati (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:We have demonstrated that vaccination with pDNA encoding cysteine proteinase Type II (CPA) and Type I (CPB) with its unusual C-terminal extension (CTE) can partially protect BALB/c mice against cutaneous leishmanial infection. Unfortunately, this protection is insufficient to completely c...