Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

• Main Authors: Yubo Wang (Author), Jian Min (Author), Xiangping Deng (Author), Tian Feng (Author), Hebing Hu (Author), Xinyi Guo (Author), Yan Cheng (Author), Baohua Xie (Author), Yu Yang (Author), Chun-Chi Chen (Author), Rey-Ting Guo (Author), Chune Dong (Author), Hai-Bing Zhou (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new mode of mechanism to fight endocrine-resistance. Given...