Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

• Hlavní autoři: Yubo Wang (Autor), Jian Min (Autor), Xiangping Deng (Autor), Tian Feng (Autor), Hebing Hu (Autor), Xinyi Guo (Autor), Yan Cheng (Autor), Baohua Xie (Autor), Yu Yang (Autor), Chun-Chi Chen (Autor), Rey-Ting Guo (Autor), Chune Dong (Autor), Hai-Bing Zhou (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2023-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new mode of mechanism to fight endocrine-resistance. Given...