Cover Image

Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new mode of mechanism to fight endocrine-resistance. Given...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yubo Wang (Author), Jian Min (Author), Xiangping Deng (Author), Tian Feng (Author), Hebing Hu (Author), Xinyi Guo (Author), Yan Cheng (Author), Baohua Xie (Author), Yu Yang (Author), Chun-Chi Chen (Author), Rey-Ting Guo (Author), Chune Dong (Author), Hai-Bing Zhou (Author)
Format:	Book
Published:	Elsevier, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Recent Advances in Covalent Drug Discovery
by: Daniel Schaefer, et al.
Published: (2023)

Targeted Covalent Inhibitors in Drug Discovery, Chemical Biology and Beyond
by: Ricardo A. M. Serafim, et al.
Published: (2024)

Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery
by: Kirsten McAulay, et al.
Published: (2022)

Systematic Exploration of Privileged Warheads for Covalent Kinase Drug Discovery
by: Zheng Zhao, et al.
Published: (2022)

Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
by: Tian Lu, et al.
Published: (2021)

Organizational and activational effects of estrogenic endocrine disrupting chemicals
by: Ellen K. Silbergeld, et al.

Organizational and activational effects of estrogenic endocrine disrupting chemicals
by: Ellen K. Silbergeld, et al.

Organizational and activational effects of estrogenic endocrine disrupting chemicals
by: Silbergeld Ellen K., et al.
Published: (2002)

New generation estrogen receptor-targeted agents in breast cancer: present situation and future prospectives
by: Jian Min, et al.
Published: (2024)

Role of estrogen receptor coregulators in endocrine resistant breast cancer
by: Kristin A. Altwegg, et al.
Published: (2021)

Highlight on lipids and its use for covalent and non-covalent conjugations
by: Abdullah Q. Khudhur, et al.
Published: (2020)

Synergistic Effect of L-Carnosine and Hyaluronic Acid in Their Covalent Conjugates on the Antioxidant Abilities and the Mutual Defense against Enzymatic Degradation
by: Valeria Lanza, et al.
Published: (2022)

Covalent Organic Frameworks
Published: (2023)

Hair regrowth in endocrine therapy alopecia with dutasteride treatment in woman with estrogen positive breast cancer
by: Celina Dubin, MD, et al.
Published: (2023)

Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals
by: Leung Peter CK, et al.
Published: (2006)

Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development
by: Aya Takesono, et al.
Published: (2022)

Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands
by: Charalampos Ntallis, et al.
Published: (2023)

Non-covalent Interactions in Coordination and Organometallic Chemistry
Published: (2022)

Oral Selective Estrogen Receptor Degraders (SERDs) in Breast Cancer: Advances, Challenges, and Current Status
by: Downton T, et al.
Published: (2022)

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist
by: Folasade R. Olayoku, et al.
Published: (2023)

Estrogen-Related Receptor γ Induces Angiogenesis and Extracellular Matrix Degradation of Temporomandibular Joint Osteoarthritis in Rats
by: Haoming Zhao, et al.
Published: (2019)

Molecular determinants of acrylamide neurotoxicity through covalent docking
by: Nicolas Pierre Friedrich Mueller, et al.
Published: (2023)

Technologies for Direct Detection of Covalent Protein-Drug Adducts
by: Elma Mons, et al.
Published: (2023)

Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
by: Miao Zheng, et al.
Published: (2024)

Organizational and activational effects of estrogenic endocrine disrupting chemicals Efeitos de organização e ativação dos desreguladores estrogênicos
by: Ellen K. Silbergeld, et al.
Published: (2002)

Commentary: Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on male reproductive system, by De Falco et al
by: Francisco José Roma Paumgartten
Published: (2015)

Optimization of small molecule degraders and antagonists for targeting estrogen receptor based on breast cancer: current status and future
by: Jiaqi Yao, et al.
Published: (2023)

Identification of covalent active site inhibitors of dengue virus protease
by: Koh-Stenta X, et al.
Published: (2015)

Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options
by: Erick Tavares Marcelino Alves, et al.
Published: (2023)

Different materials for rotator cuff repair augmentation: Intensity, degradation rate and acidity degradation products
by: Ren Shiyou, et al.
Published: (2017)

Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation
by: Katarina Vrbnjak, et al.
Published: (2024)

Protein-Targeted Degradation Agents Based on Natural Products
by: Yan Li, et al.
Published: (2022)

High-throughput modular click chemistry synthesis of catechol derivatives as covalent inhibitors of SARS-CoV-2 3CLpro
by: Feng Wang, et al.
Published: (2024)

A targeted covalent inhibitor of p97 with proteome-wide selectivity
by: Zi Ye, et al.
Published: (2022)

A RADAR-Based Assay to Isolate Covalent DNA Complexes in Bacteria
by: Katie J. Aldred, et al.
Published: (2019)

Covalent Conjugates of Allylbenzenes and Terpenoids as Antibiotics Enhancers with the Function of Prolonged Action
by: Igor D. Zlotnikov, et al.
Published: (2023)

Assuring the Biofunctionalization of Silicone Covalently Bonded to Rhamnolipids: Antibiofilm Activity and Biocompatibility
by: Maïssa Dardouri, et al.
Published: (2022)

Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors
by: Letian Song, et al.
Published: (2024)

Notch Signaling Pathway and Endocrine Resistance in Breast Cancer
by: Jing-Wen Bai, et al.
Published: (2020)

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers
by: Domenico Marson, et al.
Published: (2019)