Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation

The stirring frequency exponent of -1/2 in the theoretical Levich expression appears to apply to PAMPA and Caco-2 assays, where efficient individual-well magnetic stirring ( > 20 RPM) is used.  If a single molecule is used as a stirring calibrant, then scaling suggested by Eq. (5) with microtitre...

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Main Author: Alex Avdeef (Author)
Format: Book
Published: International Association of Physical Chemists (IAPC), 2022-12-01T00:00:00Z.
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