Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

• Main Authors: Mathieu eBourdenx (Author), Erwan eBezard (Author), Benjamin eDehay (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2014-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Neurodegenerative diseases are (i) characterized by a selective neuronal vulnerability to degeneration in specific brain regions and (ii) likely to be caused by disease-specific protein misfolding. Parkinson's disease (PD) is characterized by the presence of intraneuronal proteinacious cytoplas...