Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation

• Main Authors: Christopher G. Bunick (Author), Jonette Keri (Author), S. Ken Tanaka (Author), Nika Furey (Author), Giovanni Damiani (Author), Jodi L. Johnson (Author), Ayman Grada (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prolonged broad-spectrum antibiotic use is more likely to induce bacterial resistance and dysbiosis of skin and gut microflora. First and second-generation tetracycline-class antibiotics have similar broad-spectrum antibacterial activity. Targeted tetracycline-class antibiotics are needed to limit a...