Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks

• Autores principales: Lukas Perkhofer (Autor), Melanie Engler (Autor), Johann Gout (Autor), Frank Arnold (Autor), Mareen Morawe (Autor), Markus Breunig (Autor), Thomas Seufferlein (Autor), Alexander Kleger (Autor), Pierre-Olivier Frappart (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2019-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) is still the Achilles heel in modern oncology, with an increasing incidence accompanied by a persisting high mortality. The developmental process of PDAC is thought to be stepwise via precursor lesions and sequential accumulation of mutations. Thereby, current...