Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks

• Main Authors: Lukas Perkhofer (Author), Melanie Engler (Author), Johann Gout (Author), Frank Arnold (Author), Mareen Morawe (Author), Markus Breunig (Author), Thomas Seufferlein (Author), Alexander Kleger (Author), Pierre-Olivier Frappart (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) is still the Achilles heel in modern oncology, with an increasing incidence accompanied by a persisting high mortality. The developmental process of PDAC is thought to be stepwise via precursor lesions and sequential accumulation of mutations. Thereby, current...