Exploring the role of purinergic receptor P2RY1 in type 2 diabetes risk and pathophysiology: Insights from human functional genomics

• Main Authors: Arnaud Dance (Author), Justine Fernandes (Author), Bénédicte Toussaint (Author), Emmanuel Vaillant (Author), Raphaël Boutry (Author), Morgane Baron (Author), Hélène Loiselle (Author), Beverley Balkau (Author), Guillaume Charpentier (Author), Sylvia Franc (Author), Mark Ibberson (Author), Michel Marre (Author), Marie Gernay (Author), Marjorie Fadeur (Author), Nicolas Paquot (Author), Martine Vaxillaire (Author), Mathilde Boissel (Author), Souhila Amanzougarene (Author), Mehdi Derhourhi (Author), Amna Khamis (Author), Philippe Froguel (Author), Amélie Bonnefond (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Human functional genomics has proven powerful in discovering drug targets for common metabolic disorders. Through this approach, we investigated the involvement of the purinergic receptor P2RY1 in type 2 diabetes (T2D). Methods: P2RY1 was sequenced in 9,266 participants including 4,177 pa...