Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

• Main Authors: Huei-Fen Jheng (Author), Pei-Jane Tsai (Author), Yi-Lun Chuang (Author), Yi-Ting Shen (Author), Ting-An Tai (Author), Wen-Chung Chen (Author), Chuan-Kai Chou (Author), Li-Chun Ho (Author), Ming-Jer Tang (Author), Kuei-Tai A. Lai (Author), Junne-Ming Sung (Author), Yau-Sheng Tsai (Author)
• Format: Book
• Published: The Company of Biologists, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increased urinary albumin excretion is not simply an aftermath of glomerular injury, but is also involved in the progression of diabetic nephropathy (DN). Whereas Toll-like receptors (TLRs) are incriminated in the renal inflammation of DN, whether and how albumin is involved in the TLR-related renal...