Sphingosine 1-Phosphate Receptors: Do They Have a Therapeutic Potential in Cardiac Fibrosis?

• Ngā kaituhi matua: Ambra Vestri (Author), Federica Pierucci (Author), Alessia Frati (Author), Lucia Monaco (Author), Elisabetta Meacci (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ligand of specific G-protein coupled receptors,...