Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

• Main Authors: Anshul Budhraja (Author), Anubhav Basu (Author), Atish Gheware (Author), Dasari Abhilash (Author), Seesandra Rajagopala (Author), Suman Pakala (Author), Madhuresh Sumit (Author), Animesh Ray (Author), Arulselvi Subramaniam (Author), Purva Mathur (Author), Aruna Nambirajan (Author), Sachin Kumar (Author), Ritu Gupta (Author), Naveet Wig (Author), Anjan Trikha (Author), Randeep Guleria (Author), Chitra Sarkar (Author), Ishaan Gupta (Author), Deepali Jain (Author)
• Format: Book
• Published: The Company of Biologists, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To elucidate the molecular mechanisms that manifest lung abnormalities during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole-transcriptome sequencing of lung autopsies from 31 patients with severe COVID-19 and ten uninfected controls. Using metatranscript...