Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface

• Main Authors: Karen Peynshaert (Author), Joke Devoldere (Author), Valérie Forster (Author), Serge Picaud (Author), Christian Vanhove (Author), Stefaan C. De Smedt (Author), Katrien Remaut (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinal gene delivery via intravitreal injection is hampered by various physiological barriers present in the eye of which the vitreoretinal (VR) interface represents the most serious hurdle. In this study, we present a retinal explant model especially designed to study the role of this interface as...