Ultrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance

• Principais autores: Carol Yousry (Autor), Maha M. Amin (Autor), Ahmed H. Elshafeey (Autor), Omaima N. El Gazayerly (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Controlled-release multiparticulate systems of hydrophilic drugs usually suffer from poor encapsulation and rapid-release rate. In the present study, ultra-high loaded controlled release polymeric beads containing verapamil hydrochloride (VP) as hydrophilic model drug were efficiently prepared using...