Ultrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance

• Auteurs principaux: Carol Yousry (Auteur), Maha M. Amin (Auteur), Ahmed H. Elshafeey (Auteur), Omaima N. El Gazayerly (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Controlled-release multiparticulate systems of hydrophilic drugs usually suffer from poor encapsulation and rapid-release rate. In the present study, ultra-high loaded controlled release polymeric beads containing verapamil hydrochloride (VP) as hydrophilic model drug were efficiently prepared using...