Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

• Main Authors: Kosuke Yoshida (Author), Yuki Doi (Author), Norihiko Iwazaki (Author), Hidenori Yasuhara (Author), Yuka Ikenaga (Author), Hidetoshi Shimizu (Author), Tomohisa Nakada (Author), Tomoko Watanabe (Author), Chise Tateno (Author), Seigo Sanoh (Author), Yaichiro Kotake (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokinetics of such compounds. Although in vitro-in vivo extr...