Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers
Abstract Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CLint) often leads to significant challenges in evaluating the pharmacokinetics of such compounds. Although in vitro-in vivo extr...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-01-01T00:00:00Z.
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