Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity

• Hoofdauteurs: Alfredo G. Casanova (Auteur), Mykola Harvat (Auteur), Laura Vicente-Vicente (Auteur), Óscar J. Pellicer-Valero (Auteur), Ana I. Morales (Auteur), Francisco J. López-Hernández (Auteur), José D. Martín-Guerrero (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The clinical utility of the chemotherapeutic drug cisplatin is significantly limited by its nephrotoxicity, which is characterized by electrolytic disorders, glomerular filtration rate decline, and azotemia. These alterations are consequences of a primary tubulopathy causing injury to proximal and d...