Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia

• Main Authors: Da-ming Sui (Author), Qun Xie (Author), Wen-jing Yi (Author), Sahil Gupta (Author), Xi-ya Yu (Author), Jin-bao Li (Author), Jun Wang (Author), Jia-feng Wang (Author), Xiao-ming Deng (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis-associated encephalopathy (SAE) is characterized as brain dysfunction associated with sepsis. In this study we sought to investigate the effects of resveratrol in mice with SAE, as well as its effects in NLRP3 inflammasome and IL-1β, which were critical in the pathogenesis of SAE. SAE was ind...