Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp.

• Main Authors: Laura C Laurella (Author), Natacha Cerny (Author), Augusto E Bivona (Author), Andrés Sánchez Alberti (Author), Gustavo Giberti (Author), Emilio L Malchiodi (Author), Virginia S Martino (Author), Cesar A Catalan (Author), María Rosario Alonso (Author), Silvia I Cazorla (Author), Valeria P Sülsen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of Mikania variifolia and Mikania micrantha dichloromethane extracts. Mikanolide and deoxymikanolide were the major compounds in both extracts (2.2% and 0.4%...