Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion

• Main Authors: Viviana E. Gallardo (Author), Gaurav K. Varshney (Author), Minnkyong Lee (Author), Sujata Bupp (Author), Lisha Xu (Author), Paul Shinn (Author), Nigel P. Crawford (Author), James Inglese (Author), Shawn M. Burgess (Author)
• Format: Book
• Published: The Company of Biologists, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the last decade, high-throughput chemical screening has become the dominant approach for discovering novel compounds with therapeutic properties. Automated screening using in vitro or cultured cell assays have yielded thousands of candidate drugs for a variety of biological targets, but these app...