ALCOHOL AND ALDEHYDE DEHYDROGENASES CONTRIBUTE TO SEX-RELATED DIFFERENCES IN CLEARANCE OF ZOLPIDEM IN RATS

• Main Authors: Cody J Peer (Author), Jonathan D Strope (Author), Shaunna Beedie (Author), Ariel M Ley (Author), Alesia Holly (Author), Karim Calis (Author), Ronald Farkas (Author), Jagan Parepally (Author), Angela Men (Author), Emmanuel O Fadiran (Author), Pamela Scott (Author), Marjorie Jenkins (Author), William H. Theodore (Author), Tristan M Sissung (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives:  The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.  We hypothesized that such differences were caused by known sex...