Effects of Serine or Threonine in the Active Site of Typical 2-Cys Prx on Hyperoxidation Susceptibility and on Chaperone Activity

• Main Authors: Carlos A. Tairum (Author), Melina Cardoso Santos (Author), Carlos Alexandre Breyer (Author), Ana Laura Pires de Oliveira (Author), Vitoria Isabela Montanhero Cabrera (Author), Guilherme Toledo-Silva (Author), Gustavo Maruyama Mori (Author), Marcos Hikari Toyama (Author), Luis Eduardo Soares Netto (Author), Marcos Antonio de Oliveira (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are stable as decamers in the reduced state, and may dissociate into dimers upon disulfide bond formation. A peroxidatic Cys (C_P) takes part of a catalytic triad, together with a Thr/Ser and a...