Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update

• Hauptverfasser: Yasunari Kanda (Verfasst von), Daiju Yamazaki (Verfasst von), Tomoharu Osada (Verfasst von), Takashi Yoshinaga (Verfasst von), Kohei Sawada (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2018-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a new human cell-based platform to asse...