Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models

• Main Authors: Feng Wang (Author), Jordan C. Tsai (Author), Jonathan H. Davis (Author), Bryant Chau (Author), Jia Dong (Author), Sean M. West (Author), Jason M. Hogan (Author), Matthew L. Wheeler (Author), Christine Bee (Author), Winse Morishige (Author), Thomas Cayton (Author), Donata David-brown (Author), Chengyue Zhang (Author), Alexander Kozhich (Author), Tim Sproul (Author), Gavin Dollinger (Author), Arvind Rajpal (Author), Pavel Strop (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide insight into the role of the immune system. The...