Poly (ADP-Ribose) Polymerase 1 Mediated Arginase II Activation Is Responsible for Oxidized LDL-Induced Endothelial Dysfunction

• Main Authors: Qi Wang (Author), Tong Zhao (Author), Wei Zhang (Author), Wenbin Yu (Author), Bin Liu (Author), Zhaoyang Wang (Author), Wen Qiao (Author), Qinghua Lu (Author), Aihua Wang (Author), Mingxiang Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by competing with endothelial nitric oxide synthase (eNOS) for their same substrate L-arginine. However, the regulatory mechanisms of arginase II production remain unclear. In this study, we hypothesized that poly- (...