Computationally optimized broadly reactive vaccine based upon swine H1N1 influenza hemagglutinin sequences protects against both swine and human isolated viruses

• Main Authors: Amanda L. Skarlupka (Author), Simon O. Owino (Author), Lui P. Suzuki-Williams (Author), Corey J. Crevar (Author), Donald M. Carter (Author), Ted M. Ross (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Swine H1 influenza viruses were stable within pigs for nearly 70 years until in 1998 when a classical swine virus reassorted with avian and human influenza viruses to generate the novel triple reassortant H1N1 strain that eventually led to the 2009 influenza pandemic. Previously, our group demonstra...