Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs

• Main Authors: Wenlong Li (Author), Dilek Iusuf (Author), Rolf W. Sparidans (Author), Els Wagenaar (Author), Yaogeng Wang (Author), Dirk R. de Waart (Author), Margarida L.F. Martins (Author), Stéphanie van Hoppe (Author), Maria C. Lebre (Author), Olaf van Tellingen (Author), Jos H. Beijnen (Author), Alfred H. Schinkel (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized Oatp2b1 knockout (single Slco2b1-/- and combinati...