Elevated activity levels of activating autoantibodies to the GnRH receptor in patients with polycystic ovary syndrome

• Main Authors: Elizabeth A. Weedin, D.O., M.S (Author), Heather R. Burks, M.D (Author), Xichun Yu, M.D (Author), Hong Liang Li, M.D., Ph.D (Author), Christopher E. Aston, Ph.D (Author), David C. Kem, M.D (Author), LaTasha B. Craig, M.D (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: 1) To confirm the correlation of GnRH receptor (GnRHR) activating autoantibody (AAb) activity with polycystic ovary syndrome (PCOS) diagnosis in large well defined cohorts; and 2) to evaluate suppression of AAb activity with GnRH antagonist medication in transfected GnRHR cells exposed t...