Eupafolin suppresses TGF-β1-induced human lung fibroblasts differentiation by downregulating β-catenin/plasminogen activator inhibitor-1 signaling

• Main Authors: Mei Zhu (Author), Jian Zhang (Author), Xionghua Sun (Author), Xihua Chen (Author), Xiaogang Jiang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The anti-fibrotic activity of flavonoids from Eupatorium lindleyanum DC (EL) remains unclear. Our results showed that flavones from the plant exerted a stronger inhibitory effect than flavonols, and eupafolin presented the highest activity on lung fibroblast differentiation. Eupafolin weakened the l...