Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia

• Main Authors: Mark B. Plotnikov (Author), Galina A. Chernysheva (Author), Vera I. Smol'yakova (Author), Oleg I. Aliev (Author), Anna M. Anishchenko (Author), Olga A. Ulyakhina (Author), Eugene S. Trofimova (Author), Anastasia A. Ligacheva (Author), Nina D. Anfinogenova (Author), Anton N. Osipenko (Author), Anastasia R. Kovrizhina (Author), Andrei I. Khlebnikov (Author), Igor A. Schepetkin (Author), Anastasia G. Drozd (Author), Evgenii V. Plotnikov (Author), Dmitriy N. Atochin (Author), Mark T. Quinn (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activation of <i>c</i>-Jun N-terminal kinase (JNK) plays an important role in stroke outcomes. Tryptanthrin-6-oxime (TRYP-Ox) is reported to have high affinity for JNK and anti-inflammatory activity and may be of interest as a promising neuroprotective agent. The aim of this study wa...