Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity t...
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Main Authors: | , , , , , , , , , , , , , , , , , |
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格式: | 图书 |
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Elsevier,
2022-06-01T00:00:00Z.
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A1234.567 |
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