Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity t...

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Main Authors: Peilu Song (Author), Fan Zhao (Author), Dahong Li (Author), Jiqiang Qu (Author), Miao Yao (Author), Yuan Su (Author), Hanxun Wang (Author), Miaomiao Zhou (Author), Yujie Wang (Author), Yinli Gao (Author), Feng Li (Author), Dongmei Zhao (Author), Fengjiao Zhang (Author), Yu Rao (Author), Mingyu Xia (Author), Haitao Li (Author), Jian Wang (Author), Maosheng Cheng (Author)
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出版: Elsevier, 2022-06-01T00:00:00Z.
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索引号: A1234.567
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