A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure

• Main Authors: Abhishek G. Sathe (Author), Richard C. Brundage (Author), Vijay Ivaturi (Author), James C. Cloyd (Author), James M. Chamberlain (Author), Jordan J. Elm (Author), Robert Silbergleit (Author), Jaideep Kapur (Author), Lisa D. Coles (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Estimating early exposure of drugs used for the treatment of emergent conditions is challenging because blood sampling to measure concentrations is difficult. The objective of this work was to evaluate predictive performance of two early concentrations and prior pharmacokinetic (PK) informa...