Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar.

• Main Authors: Nicole A P Lieberman (Author), Michelle J Lin (Author), Hong Xie (Author), Lasata Shrestha (Author), Tien Nguyen (Author), Meei-Li Huang (Author), Austin M Haynes (Author), Emily Romeis (Author), Qian-Qiu Wang (Author), Rui-Li Zhang (Author), Cai-Xia Kou (Author), Giulia Ciccarese (Author), Ivano Dal Conte (Author), Marco Cusini (Author), Francesco Drago (Author), Shu-Ichi Nakayama (Author), Kenichi Lee (Author), Makoto Ohnishi (Author), Kelika A Konda (Author), Silver K Vargas (Author), Maria Eguiluz (Author), Carlos F Caceres (Author), Jeffrey D Klausner (Author), Oriol Mitjà (Author), Anne Rompalo (Author), Fiona Mulcahy (Author), Edward W Hook (Author), Sheila A Lukehart (Author), Amanda M Casto (Author), Pavitra Roychoudhury (Author), Frank DiMaio (Author), Lorenzo Giacani (Author), Alexander L Greninger (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective vaccine to curtail t...