Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder

• Main Authors: Anna M. Gutridge (Author), Soumen Chakraborty (Author), Balazs R. Varga (Author), Elizabeth S. Rhoda (Author), Alexander R. French (Author), Arryn T. Blaine (Author), Quinten H. Royer (Author), Haoyue Cui (Author), Jinling Yuan (Author), Robert J. Cassell (Author), Márk Szabó (Author), Susruta Majumdar (Author), Richard M. van Rijn (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose:Mitragyna speciosa extract and kratom alkaloids decrease alcohol consumption in mice at least in part through actions at the δ-opioid receptor (δOR). However, the most potent opioidergic kratom alkaloid, 7-hydroxymitragynine, exhibits rewarding properties and hyperlocomotion p...